1353 Contribution of YBX1 phosphorylation in human epidermal stem cell aging

The RNA binding protein YBX1 is a key regulator of epidermal progenitor cell senescence that prevents the mRNA translation critical senescence-associated secretory phenotypes (SASP) transcripts such as CXCL1 and IL8. Decreased levels during aging enables production SASP-related proteins subsequent induction senescence. Posttranslational modifications YBX1, phosphorylation at Ser 102, can modify intracellular localization diminish its capacity. In this study, we investigated role in human skin aging. While MCSP-positive stem/progenitor cells with YBX-1 expression be found abundantly young sun-protected skin, their numbers photoaged decrease. addition, level phosphorylated was increased. Since by PI3 kinase, kinase inhibitors PI-103 GDC-0941 restrict prevent keratinocyte ex vivo cultured increased cells. promising cosmetic ingredient suppresses phosphorylation, decreases IL-8 production, maintains stem conclusion, contributes to aging, inhibition novel anti-aging approach maintaining healthy